re: timeline and Ho 28 October 2004
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James I Madigan,
student, MS nutrition
New Brunswick, NJ 08901

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Re: re: timeline and Ho

Nicholas Bennett wrote: " [..] I'd be happy to email James >Madigan the introduction to my thesis as one place to start, since it goes through the basics of the story.

>For example, Ho found that HIV was replicating rapidly by measuring the rate of virus RNA decline (by PCR) once antivirals were initiated. A decline of X with a baseline level of Y would imply a replication rate of Z. [1]

>Nick Bennett


>1. Perelson et al. Science. 1996 Mar 15;271(5255):1582-6. "HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time." "

I am assuming that reference is the relevant Ho paper (though he is not listed as an author). It sounds a rather obscure way to "prove" high levels of virus, particularly in view of Kary Mullis's well-known objections.

If you can recall, what virus levels did he conclude were in the (as I recall) in vivo lymphoid tissue? Was it claimed to be whole virions?

Certainly email your introduction if you wish - jimadigan(at)

Competing interests: None declared