Re: Aids paradigm timeline 26 October 2004
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Nicholas Bennett,
Infectious Disease Postdoc/Clinician
Department of Pediatrics, University Hospital, Syracuse NY

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Re: Re: Aids paradigm timeline

Concise is the problem ;-) It is a 20 year story with several false starts and dead ends. I'd be happy to email James Madigan the introduction to my thesis as one place to start, since it goes through the basics of the story.

For example, Ho found that HIV was replicating rapidly by measuring the rate of virus RNA decline (by PCR) once antivirals were initiated. A decline of X with a baseline level of Y would imply a replication rate of Z. [1]

Nick Bennett njb35@cantab.net

refs:

1. Perelson et al. Science. 1996 Mar 15;271(5255):1582-6. "HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time."

Competing interests: None declared