HTLV a lentivirus? 25 October 2004
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Eleni Papadopulos-Eleopulos,
Biophysicist
Department of Medical Physics, Royal Perth Hospital, Western Australia, 6001,
Valendar F Turner, John Papadimitriou, Barry Page, David Causer, Helman Alfonso, Sam Mhlongo, Todd Miller, Christian Fiala

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Re: HTLV a lentivirus?

HTLV a lentivirus?

In his rapid response: "Re: AIDS and the making of the Public Mind", 13 October, Nicholas Bennett wrote: "HIV transmission can be demonstrated in animal models (the same animal models that some like, the Perth Group claim do not exist".

Yes, you do claim that to date no "HIV"/AIDS animal model exists. Would Nicholas Bennett please give us one main reference and a few confirmatory studies with evidence which proves the existence of such models.

Nicholas Bennett wrote: "The prototypical lentivirus in fact isn't even human - maedi visna virus, in sheep. Aside from the old onco-, lenti- , spuma- virus classification, the more recent A, B, C, and D type classification has been modified also in recent years: based as it was on EM visual appearance and not the actual genetic relationship of the viruses. Under the new classification, some classical "lentiviruses" such as HTLV are no longer called that even though the original meaning (lenti- slow) applied to the clinical aspects of the infection. The old C-type viruses, which HIV resembles structurally, have been reclassified into two new groups, neither of which include complex retroviruses."

According to Gallo, Miyoshi, that is the discoverers of HTLV, "Human T-cell leukaemia-lymphoma virus (HTLV) is a type-C retrovirus". [1 2] The type-C retroviruses belong to the sub-family of oncovirinae. [3 4] Nobody except Nicholas Bennett has ever claimed that HTLV (I, II) is a lentivirus, much less a "classical", "lentivirus".

Since the late 1980s, with one exception, [5] everybody including Montagnier[6] and Hans Gelderblom [7], have maintained that "structurally" HIV resembles lentiviruses.

Nicholas Bennett wrote: "The references he [Chris Tyler] supplied were actually quite intriguing, and while they don't support AZT being "oxidative" they do add to the understanding of AZT-mediated mitochondrial toxicity (which then, subsequently, affects the redox state). I found the precis and evidence rather better presented that what the Perth Group usually churn out. I interpret the findings slightly differently, in that the AZT-mediated mitochondrial toxicity is linked to alterations in GSH, rather than a direct cause through a chemical redox reaction".

This is a most revealing statement. And, given Nicholas Bennett's repeated criticisms of our oxidative theory of AIDS, totally unexpected. In Nicholas Bennett's view, "AZT-mediated mitochondrial toxicities is linked to alterations in GSH", "which then, subsequently, affects the redox state". Amazing. Would Nicholas Bennett please tell us what he understands by cellular redox, what are its determinants and what is his understanding of our oxidative theory of AIDS? As well as our proposed mechanism of AZT toxicity. Before Nicholas Bennett repeats such statements as: "The oxidative stress theory of holes in the head is an illustration of the pseudoscience principles,…" would he please read all our published work on the oxidative theory of AIDS (easily accessible on our website) including A critical analysis of the pharmacology of AZT and its use in AIDS.[8]

Would Nicholas Bennett please also read “A Mitotic Theory”, [9] a general theory of biological functioning based on the dynamics of cellular redox. The oxidative theory of AIDS is based on this paper and “The Mitotic Theory” predicts both the onset of AIDS diseases and the laboratory phenomena claimed to prove the existence of “HIV”.

References

1. Popovic M, Sarin PS, Robert-Gurroff M, Kalyanaraman VS, Mann D, Minowada J, et al. Isolation and transmission of human retrovirus (human t -cell leukemia virus). Science 1983;219:856-9. 2. Miyoshi I. Biology of T-cell leukemia virus: search for an animal system. Current Topics in Microbiologh and Immunology 1985;115:143-56.

3. Frank H. Retroviridae. In: Nermut MV, Steven AC, editors. Animal Virus and Structure. Oxford: Elsevier, 1987:253-256.

4. Frank H. Oncovirinae: type C oncovirus. In: Nermut MV, Steven AC, editors. Perspectives in Medical Virology. New York: Elsevier, 1987:273- 287.

5. Kuznetsov YG, Victoria JG, Robinson WE, Jr., McPherson A. Atomic force microscopy investigation of human immunodeficiency virus (HIV) and HIV-infected lymphocytes. J Virol 2003;77:11896-909.

6. Montagnier L. Virus. .New York: WW Norton & Company Inc, 1999. 7. Gelderblom HR, Hausmann EH, Ozel M, Pauli G, Koch MA. Fine structure of human immunodeficiency virus (HIV) and immunolocalization of structural proteins. Virol 1987;156:171-6.

8. Papadopulos-Eleopulos E, Turner VF, Papadimitriou JM, Causer D, Alphonso H, Miller T. A critical analysis of the pharmacology of AZT and its use in AIDS. Curr Med Res Opinion 1999;15:1s-45s.

9. Papadopulos-Eleopulos E. A Mitotic Theory. J Theor Biol 1982;96:741-758. http://www.theperthgroup.com/EPE/MitoticTheory.pdf

Competing interests: None declared