"HIV" and AIDS 16 October 2004
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Eleni Papdopulos-Eleopulos,
Biophysicist
Department of Medical Physics, Royal Perth Hospital, Western Australia, 6001,
Valendar F Turner, John Papadimitriou, Barry Page, David Causer, Helman Alfonso, Sam Mhlongo, Todd Miller, Christian Fiala

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Re: "HIV" and AIDS

"HIV" and AIDS

In his rapid response: "Re: "HIV" and KS", 18 August, Nicholas Bennett gave his view on the "mechanism by which HIV causes AIDS".

In our rapid response: "Mechanisms by which HIV causes AIDS", 29 September, we have pointed out that Nicholas Bennett did not give any references in support of his claim and that it is not possible to talk about a mechanism before there is evidence which proves the "HIV" theory of AIDS. In his rapid response" "HIV mechanism revisited", 2 October, Nicholas Bennett gave references which he claims contain evidence in support of the "mechanism by which HIV causes AIDS". He also gave us a long story but did not respond to what we consider to be critical problems with the "HIV" theory of AIDS.

So, let us reconsider them once again. Would Nicholas Bennett please tell us, is it true that according to the "HIV" theory of AIDS:

(a) all AIDS patients are infected with "HIV";

(b) "HIV" kills the T4 cells;

(c) decrease in T4 cells leads to the appearance of the clinical syndrome.

(d) T4 cell decrease is the "hallmark" and "gold standard" of HIV infection[1, 2].

Yes or no.

1. HIV infection

Would Nicholas Bennett please tell us, is it true that at present only two tests are routinely used to prove infection with HIV, namely antibodies and PCR (DNA and RNA). Yes or no.

According to "HIV" researchers (not the Perth Group) and test kit manufacturers, "at present there is no recognised standard for establishing the presence or absence of HIV-1 antibodies in human blood",[3] and that "it may be impossible to relate an antibody response specifically to HIV-1 infection" [4, 5].

Yes or no.

According to the "HIV" experts and test kit manufacturers (not the Perth Group) there are even more problems with the PCR (both, DNA and RNA) than with the antibody tests and for this reason the test should "NOT" be used for the diagnosis of "HIV" infection [6-11].

Would Nicholas Bennett please tell us, does not this mean that at present no proof exists for what percentage, if any, of AIDS patients are infected with "HIV"? Yes or no.

2. "HIV" and T4 cells

Montagnier and Gallo have shown that: (i) "HIV" + stimulation = decrease in T4 cells; (ii) stimulation by itself = decrease in T4 cells; (iii) "HIV" by itself = no effect [12-14].

Would Nicholas Bennett please tell us, does the Montagnier and Gallo data show that: (i) "HIV" does not kill or decrease the T4 cells by any means;

Yes or no.

(ii) Since the AIDS patients are exposed to repeated stimulation ("infections with various microorganisms", "allogenic cells such as semen or blood", drugs (including factor VIII), the cause of the T4 decrease in these patients is the stimulation and not "HIV".

Yes or no.

3. T4 cells and the syndrome

In his rapid response: ""HIV mechanism revisited", 2 October, Nicholas Bennett wrote: "It's not so much that all individuals with low CD4 count should get AIDS OI's [opportunistic infections], or that all people with AIDS-OIs will have low CD4 counts".

Would Nicholas Bennett please tell us: (i) If not "all people with AIDS-OI's will have a low CD4 count" does it not mean that low CD4 (immune deficiency) is not necessary for the syndrome, including opportunistic infections, to appear? (ii) If low CD4 counts are not necessary for the appearance of the clinical syndrome, must not any scientist worth his salt question the "HIV" theory of AIDS?

References

1. Levacher M, Hulstaert F, Tallet S, Ullery S, Pocidalo JJ, Bach BA. The significance of activation markers on CD8 lymphocytes in human immunodeficiency syndrome: staging and prognostic value. Clin Exp Immunol 1992;90:376-382.

2. Shaw MS, Wong-Staal F, Gallo RC. Etiology of AIDS: virology, molecular biology, and evolution of human immunodeficiency viruses. In: DeVita VT, Hellman S, Rosenberg SA, editors. AIDS Etiology, Diagnosis, Treatment and Prevention. 2nd ed. Philadelphia: J.B. Lippincott Company, 1988.

3. Packet Insert Axsym system (HIV-1/HIV-2). Abbott Laboratories Diagnostics Division. 100 Abbott Park Rd. Abbott Park. Illinois: United States of America. 1988, 1998.

4. Blattner WA. Retroviruses. In: Evans AS, editor. Viral infections of humans. 3rd ed. New York: Plenum Medical Book Company, 1989:545-592.

5. Mortimer PP. The AIDS virus and the AIDS test. Med Internat 1988;56:2334-2339. 6. CDC. Guidelines for national human immunodeficiency virus case surveillance, including monitoring for human immunodeficiency virus infection and acquired immunodeficiency syndrome. Centers for Disease Control and Prevention. Morb Mortal Wkly Rep 1999;48:1-27, 29-31.

7. GenProbe Incorporated. Procleix HIV-1/HCV Assay, 2002.

8. Chrystie IL. Screening of pregnant women: the case against. Pract Midwife 1999;2:38-39.

9. Boriskin YS, Booth JC, Roberts MM, Carrington D, Coates ARM. HIV primers can amplify sequences of human satellite DNA. AIDS 1994;8:709-711.

10. Mortimer PP. Ten years of laboratory diagnosis of HIV: how accurate is it now? J Antimicrob Chemother 1996;37:B. 27-32.

11. Owens DK, Holodniy M, Garber AM, Scott J, Sonnad S, Moses L, et al. Polymerase chain reaction for the diagnosis of HIV infection in adults. A meta-analysis with recommendations for clinical practice and study design. Ann Int Med 1996;124:803-15.

12. Laurent-Crawford AG, Krust B, Muller S, Rivière Y, Rey-Cuillé M- A, Béhet J-M, et al. The Cytopathic Effect of HIV is Associated with Apoptosis. Virol 1991;185:829-839.

13. Klatzmann D, Champagne E, Chamaret S, Gruest J, Guetard D, Hercend T, et al. T-lymphocytes T4 molecule behaves as the receptor for human retrovirus LAV. Nature 1984;312:767-768.

14. Zagury D, Bernard J, Leonard R, Cheynier R, Feldman M, Sarin PS, et al. Long-Term Cultures of HTLV-III-Infected T Cells: A Model of Cytopathology of T-Cell Depletion in AIDS. Science 1986;231:850-853.

Competing interests: None declared