"HIV" and PCP 14 October 2004
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Eleni Papadopulos-Eleopulos,
Biophysicist
Department of Medical Physics, Royal Perth Hospital, Western Australia, 6001,
Valendar F Turner, John Papadimitriou, Barry Page, David Causer, Helman Alfonso, Sam Mhlongo, Todd Miller, Christian Fiala

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Re: "HIV" and PCP

"HIV" and PCP

In his rapid response: "Re: "HIV" a necessary or sufficient cause" for AIDS?", 30 September 2004, Peter Flegg wrote: "The remainder of the references merely confirm one thing: If you see any cases of PCP in the absence of HIV infection, write them up for journal publication quickly, since they are extremely unusual! I thank the Perth Group for their help in demonstrating the rarity of non-HIV PCP, and confirming Chris Noble's views."

The only thing the evidence in the five references in our rapid response: ""HIV" "a necessary or sufficient cause" for AIDS?" as well as elsewhere (see E Papadopulos-Eleopulos et al, Genetica 1995; 95:25-50) confirms is that:

(i) PCP is over diagnosed in the AIDS risk groups; (ii) PCP is under-diagnosed in individuals who do not belong to the AIDS risk groups.

Can the diagnosis of PCP in five immunocompetent, "HIV" negative individuals in one hospital, within 3 months, be considered as evidence that PCP is "extremely unusual" in the absence of "HIV"?

Competing interests: None declared