Mice May Have Good Reason to Fear Male Pigs 17 September 2004
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Tony Floyd,
Medical Student
Newcastle University

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Re: Mice May Have Good Reason to Fear Male Pigs

In addition to recently misrepresenting the work of Jay Levy, the 'Perth Group' stated that:

> A person can get CD4 counts of less than 50 per microliter and immune suppression by repeated exposure to: drugs,1 2 semen, 3-6 ...

With reference number 5 given as:

5. Dostal J, Veselsky L, Drahorad J, Jonakova V. Immunosuppressive effect induced by intraperitoneal and rectal administration of boar seminal immunosuppressive factor. Biol Reprod 1995;52:1209-14.

With all due respect to Peter Flegg's "forlorn hope that for once, just once, references used by the Perth Group might have been cited accurately" I've read the article above and, possibly to nobody's surprise, it does not say anything about semen reducing a person's CD4 counts to less than 50 per microliter. Were they once again hoping that nobody would check the article that they were citing? The authors did find that boar seminal plasma had an immunosuppressive effect when inserted rectally into a male mouse. No problems in conceding something that the authors did actually find, but on what line number and on what page do you find evidence for the statement regarding human CD4 counts?

The authors have more recently shown similar results from the intrauterine infusion of boar seminal plasma. (1) They again made no bold statement as to a specific human CD4 count.

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References:

(1) Dostal J, Zelezna B, Jonakova V, Veselsky L. Immunolocalization of the boar seminal immunosuppressive fraction infused via uterus on the lymphocytes populating mouse genital tract tissues. Folia Biol (Praha). 2000;46(2):59-68.

Competing interests: None declared