MORE ON RADIATION AND OXIDATION 17 September 2004
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Eleni Papadopulos-Eleopulos,
Biophysicist
Department of Medical Physics, Royal Perth Hospital, Western Australia, 6001,
Valendar F Turner, John Papadimitriou, Barry Page, David Causer, Helman Alfonso, Sam Mhlongo, Todd Miller, Christian Fiala

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Re: MORE ON RADIATION AND OXIDATION

MORE ON RADIATION AND OXIDATION

In his rapid response: "Various responses to the Perth Group", 9 September, Nicholas Bennett wrote: "Contrary to the Perth Group's 1975- based theory on SH groups, the action of UV light is purely and simply to catalyse covalent modification of the DNA strand. Photons carry a certain amount of electromagnetic energy, as it happens. Eyesight is testimony to that…as is Einstein's work."

Would Nicholas Bennett please tell us what is the basic mechanism by which UV light causes "covalent modification of the DNA strand"?

As was clearly stated in our rapid response: "Cell death, radiation and oxidation", 7 September, the notion that protein SHs are critically involved in cellular survival following irradiation is not ours, and is not a theory but experimental evidence. This was shown by Warren Sinclair from the Division of Biological and Medical Research, Argone National Laboratory. Our contribution was to show that the SH were those of the acid soluble proteins.

If Nicholas Bennett wants more recent evidence all he has to do is read James Whitehead's rapid response, "Re: Cell death, radiation and oxidation", 8 September.

Competing interests: None declared