Requests to Christopher Noble and Nicholas Bennett 8 September 2004
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Eleni Papadopulos-Eleopulos,
Biophysicist
Department of Medical Physics, Royal Perth Hospital, Western Australia, 6001,
Valendar F Turner, John Papadimitriou, Barry Page, David Causer, Helman Alfonso, Sam Mhlongo, Todd Miller, Christian Fiala

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Re: Requests to Christopher Noble and Nicholas Bennett

Requests to Christopher Noble and Nicholas Bennett

In his rapid response: "Re: Water and semen; the same carcinogenic properties?", 3 September, Nicholas Bennett wrote: "HHV8 is fairly carcinogenic since it contains several tumour-causing genes, can be found in all cases of KS (and many of Castleman's disease) and is epidemiologically associated with the various tumours. Can the Perth Group explain why the ubiquitous exposure of semen is only associated with KS in the presence of HHV8 infection?"

In his rapid response: "Re: Water and semen: the same carcinogenic properties", 3 September, Christopher Noble wrote: "The evidence connecting HPV with anal and cervical cancer is much stronger than the weak correlations that the Perth Group scrape together for their own hypotheses.

It should be obvious to most people by now that the Perth Group are operating outside of modern science and intellectual reason."

Would Christopher Noble and Nicholas Bennett please give us:

(a) the theoretical evidence on which their claim for the carcinogenic effects of HHV8 and HPV is based;

(b) the evidence from a main epidemiological study and a few confirmatory studies showing that HHV8 causes KS;

(c) if "HHV8 is fairly clearly carcinogenic since it contains several tumour-causing genes", what are the cancers it causes?;

(d) the evidence from a main epidemiological study and a few confirmatory studies showing that HPV causes cervical and anal cancers;

(e) the experimental evidence from a main study and a few confirmatory studies showing that: (i) HHV8 causes cancer including KS; (ii) HPV causes cancer.

Since all the sexually transmitted infectious agents and thus the disease they cause are bidirectionally transmitted, that is, from the active to the passive partner and from the passive to the active partner, would Nicholas Bennett and Christopher Noble please give us the evidence from a main study and from a few confirmatory studies showing that the cancers "caused" by HHV8 and HPV are bidirectionally transmitted.

Competing interests: None declared