Re: Re: "HIV" and KS 3 September 2004
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James J Whitehead,
Long term Survivor of hiv/oxidative stress/aids Researcher Continuum Magazine,Member of www.altheal.
40A Josephine Avenue ,London, SW2 2LA, United Kingdom

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Re: Re: Re: "HIV" and KS

Dear Nicholas bennett,

Thank you for your data and references they where very interesting as is your point of view.

However you stated in reply to Alex Russle :

"KS is found with HHV8 in 100% of samples from all forms of KS, there is really no need to invoke any kind of drug abuse as a causal agent. That's not to say that (like HIV) it may augment the action of HHV8, but that's not the same as saying HHV8 doesn't cause KS."

You later stated in reply to The Perth Group :

"There is huge evidence that HHV8 is found in 95-100% of KS cases, of all types [1-3]. The references provided are merely a smattering of those that exist, chosen at random."

I am sure you cannot be refering to hhv-8 antibody tests or hhv-8 antibody titre levels ?

"The seroprevalence of KSHV was 79% (63/80) in those with Kaposi's sarcoma as compared to 50% (302/607) in those without (chi(2) heterogeneity (1 df) = 21.0; p < 0.001) and the risk of the tumour increased with increasing anti-KSHV antibody titres (chi(2) trend (1 df) = 29.7; p < 0.001)." .(10).(Risk factors for Kaposi's sarcoma: a case- control study of HIV-seronegative people in Uganda.)" (from my previous submissions)

"J Infect Dis. 1998 Aug;178(2):304-9. Comment in: J Infect Dis. 1999 Jun;179(6):1591-2.

Interassay correlation of human herpesvirus 8 serologic tests. HHV-8 Interlaboratory Collaborative Group.

Rabkin CS, Schulz TF, Whitby D, Lennette ET, Magpantay LI, Chatlynne L, Biggar RJ.

Viral Epidemiology Branch, National Cancer Institute, Bethesda, Maryland, USA.

To standardize human herpesvirus 8 (HHV-8) antibody assays for application to asymptomatic infection, a blinded comparison was done of seven immunofluorescence assays and ELISAs. Five experienced laboratories tested a serum panel from 143 subjects in 4 diagnostic groups. Except for a minor capsid protein ELISA, the other six tests detected HHV-8 antibodies most frequently in classic (80%-100%)

and AIDS-related (67%-91%) Kaposi's sarcoma,

followed by human immunodeficiency virus-seropositive patients (27%- 60%), and least frequently in healthy blood donors (0-29%).

However, these six assays frequently disagreed on individual sera, particularly for blood donor samples.

Current HHV-8 antibody tests have uncertain accuracy in asymptomatic HHV-8 infection and may require correlation with viral protein or nucleic acid detection.

Antibody assays are useful for epidemiologic investigations, but the absolute prevalence of HHV-8 infection in the United States cannot yet be determined. "

Mr Christopher Nobel states:

"The prevalence of HHV-8 is low in heterosexuals in the West and yes HHV-8 has a high prevalence in the populations that have a high incidence of classic KS. Kaposi's sarcoma and other manifestations of human herpesvirus 8."

I found this statement interesting. Please go here to find data that invalidates and contradicts this statement. et_message&mview=0&ID_Message=8565&LastModifie d=4675487362475069560

Best Wishes

Yours Faithfully

James J Whitehead member of and

Competing interests: Long term Survivor of hiv/oxidative stress/aids Researcher Continuum Magazine,Member of , clinnical trials volunteer