Alexander H Russell,
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Regarding KS and 'HIV' Dr. Christopher J Noble stated: "HIV is generally accepted to play a role in KS firstly by causing immunesuppression and secondly by the interaction of HIV tat with HHV-8."
This statement is pure science fiction: we do not have any evidence that the putative 'HIV' causes "immunesuppression". The tat gene may very well be an endogenous cellular gene and not a viral one. Dr. Noble continues with more science fiction: "There unquestionably is evidence that HIV is causally related to KS."
What is this 'evidence'? Even the CDC admit that this is not true: (Beral, V., Peterman, T.A., Berkelman, R.L. & Jaffe, H.W. Lancet 335, 123-128 (1990). Redfield, R.R. & Burke, D.S. Sci. Am. 259, 70-78 (1988). The CDC acknowledges that 'HIV' plays no role, either directly or indirectly, in the development of KS. And even 'HIV' Fundamentalist, Dr. Robert Gallo, stated that 'HIV' plays no role in KS.
Moreover, Harry Haverkos noted that there are homosexual cases of ' HIV negative' KS. In the wealthy West there is very little KS is found outside the homosexual population. There are said to be four types of KS:
1. Classic KS, occurring among older men, indolent.
2. African KS: 25-40 age group, first indolent then fatal in 5-8 years.
3. Iatrogenic KS (e.g., renal transplant): indolent or fulminant.
4. Epidemic or AIDS KS: homosexuals: now often reversible and non fatal unless it gets to the lungs.
Dr. Noble goes on: "The evidence linking 'HHV-8' and KS is much stronger than that for poppers." If this is the case, where are all the sex workers with 'HHV-8' who have KS? Why is KS almost exclusively restricted to homosexuals who use poppers? To find HHV-8 in cases of KS is hardly surprising as it appears to be ubiquitous. In which case why should it only cause the typical legions observed in gay men who snort nitrite inhalants (poppers)? Why does a ubiquitous virus 'HHV-8' only seem to cause KS in homosexuals? Is 'HHV-8' a real virus and ever been isolated - or is it yet another guessing games virtual virus like 'HIV' detected by surrogate markers? What does 'HHV-8' look like? Yet another multicoloured mosaic? When will they be inventing 'HHV-9'?
While Dr. Noble sated that there are many published electronmicrographs of 'HIV' when in fact there are nothing of the kind. To date there are no published electronmicrographs showing densely packed 'HIV' viral particles but only nebulous images showing a collage cellular debris which act as a marker for either poverty or risk behaviour.
BMJ readers may have noted that Dr. Noble seems to have penchant for virtual viruses. How can a non-existent entity ('HIV') be 'related' to anything? In reality 'HIV' stands for the 'human imaginary virus'.
Peter Duesberg and David Rasnick on KS Kaposi's sarcoma is at least 20 times more common among homosexual than among non-homosexual AIDS patients (page 90) (Haverkos & Dougherty, 1988b; Beral et al., 1990; Chamberland & Curran, 1990). Based on the correlation between the new epidemic of homosexual Kaposi's sarcomas and the almost exclusive use of nitrites by male homosexuals, it was originally proposed in the early 1980s that nitrites were the cause (Durack, 1981; Marmor et al., 1982; Newell et al., 1984; Haverkos et al., 1985; Newell et al., 1985b).
Moreover, the nitrite-Kaposi hypothesis is directly supported by clinical distinctions between the Kaposi's of the AIDS era and those originally described by Moritz Kaposi in the last century (Kaposi, 1872). The 'HIV-associated' sarcomas are 'aggressive and life-threatening' (Sloand et al., 1993), and fatal within 8-10 months after diagnosis (Meduri et al., 1986; Garay et al., 1987; Gill et al., 1989; Irwin & Kaplan, 1993). In contrast, the classic 'indolent and chronic' Kaposi's sarcomas hardly progress over many years (Meduri et al., 1986; Drotman & Haverkos, 1992; Cohen, 1994a). Further, Kaposi had diagnosed sarcomas only on the skin, mostly of the lower extremities, but up to 32% of the Kaposi's sarcomas of homosexual men are lung cancers (Gill et al., 1989; Irwin & Kaplan, 1993). Pulmonary Kaposi's sarcoma had never been observed by Moritz Kaposi in the last century, nor by anyone else prior to the AIDS epidemic (Kaposi, 1872). Because the lungs are the primary site of exposure to nitrite inhalants, pulmonary Kaposi's sarcoma is further support for the nitrite-Kaposi hypothesis.
Genetica 104: 85-132, 1998: Duesberg & Rasnick
Competing interests: None declared