Don't Let Inconsistent Denialists Get the 'Bess' of you... 21 July 2004
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Tony Floyd,
Medical Student
Newcastle University

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Re: Don't Let Inconsistent Denialists Get the 'Bess' of you...

In a 'Perth Group' Response from 22nd May 2003 they referred to:

> Julian Bess, for whom we have the highest regard

And yet on 19th July 2004, amongst other attempts to deride the paper he wrote with Zhu (1), you describe his work as:

> unlike the "tomogram sections from a SIVmac239", the reconstructed surface of the "HIV" tomogram is far from convincing. (emphasis mine)

Why the change in your faith in Julian Bess?

Is it his continued work to find a vaccine for a virus that you claim doesn't exist? Or the fact that he has never published anything to support your repeated claims regarding his 1997 paper (2)?

or do you refer to a different Julian Bess? You never explained why, given your professed support of his work, he also published this (3):

"Importantly, the presence of CD45 on microvesicles but not on virions may provide a way in which to purify HIV-1 virions of contaminating microvesicles. Microvesicle-free HIV-1 preparations would have practical applications for biochemical analyses. The ability to remove microvesicles from purified virus preparations may also be advantageous for the production of inactivated HIV-1 vaccines."

Which would indicate that he has no delusions as to which are the microvesicles and which are the virions.

References:

(1) Zhu P, Chertova E, Bess J Jr, Lifson JD, Arthur LO, Liu J, Taylor KA, Roux KH. Electron tomography analysis of envelope glycoprotein trimers on HIV and simian immunodeficiency virus virions. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15812-7. PMID: 14668432

(2) Bess JW Jr, Gorelick RJ, Bosche WJ, Henderson LE, Arthur LO. Microvesicles are a source of contaminating cellular proteins found in purified HIV-1 preparations. Virology. 1997 Mar 31;230(1):134-44. PMID: 9126269

(3) Esser MT, Graham DR, Coren LV, Trubey CM, Bess JW Jr, Arthur LO, Ott DE, Lifson JD. Differential incorporation of CD45, CD80 (B7-1), CD86 (B7-2), and major histocompatibility complex class I and II molecules into human immunodeficiency virus type 1 virions and microvesicles: implications for viral pathogenesis and immune regulation. J Virol. 2001 Jul;75(13):6173-82. PMID: 11390619

Competing interests: None declared