Brian T Foley,
Los Alamos National Lab, Los Alamos, NM 87545
Send response to journal:
Re: I stand corrected re: gp120 lost in centrifugation
previously stated that gp120 was attached to viral particles by weak
forces and was often lost during centrifugation. Chris Noble pointed
out to me that this may not be true, based on a publication by Elena
Chertova E, Bess Jr JW Jr, Crise BJ, Sowder II RC,
Schaden TM, Hilburn JM, Hoxie JA, Benveniste RE,
Lifson JD, Henderson LE, Arthur LO.
Envelope glycoprotein incorporation, not shedding of
surface envelope glycoprotein (gp120/SU), Is the primary
determinant of SU content of purified human
immunodeficiency virus type 1 and simian immunodeficiency
J Virol. 2002 Jun;76(11):5315-25.