I stand corrected re: gp120 lost in centrifugation 25 June 2004
Previous Rapid Response Next Rapid Response Top
Brian T Foley,
HIV Researcher
Los Alamos National Lab, Los Alamos, NM 87545

Send response to journal:
Re: I stand corrected re: gp120 lost in centrifugation

I previously stated that gp120 was attached to viral particles by weak forces and was often lost during centrifugation. Chris Noble pointed out to me that this may not be true, based on a publication by Elena Chertova (1).

REFERENCE:
Chertova E, Bess Jr JW Jr, Crise BJ, Sowder II RC,
Schaden TM, Hilburn JM, Hoxie JA, Benveniste RE,
Lifson JD, Henderson LE, Arthur LO.
Envelope glycoprotein incorporation, not shedding of
surface envelope glycoprotein (gp120/SU), Is the primary
determinant of SU content of purified human
immunodeficiency virus type 1 and simian immunodeficiency
virus.
J Virol. 2002 Jun;76(11):5315-25.
PMID: 11991960

Competing interests: None declared