A QUESTION AND A REQUEST TO BRIAN FOLEY 12 May 2004
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Eleni Papadopulos-Eleopulos,
Biophysicist
Department of Medical Physics, Royal Perth Hospital, Western Australia, 6001,
Valendar F Turner, John Papadimitriou, Barry Page, David Causer, Helman Alfonso, Sam Mhlongo, Todd Miller, Christian Fiala

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Re: A QUESTION AND A REQUEST TO BRIAN FOLEY

A QUESTION AND A REQUEST TO BRIAN FOLEY

We are pleased that in his rapid response, “Re: Re-phrasing our two questions to Brian Foley”, 11th May 2004, Brian Foley agrees with us that the HIV clones (the “HIV” genome) including some of the best known and most often used in “HIV” research described by Gallo and Montagnier’s groups originated either directly or indirectly from the poly(A)-RNA present in the 1.16g/ml band.

Is it true that the poly(A)-RNA is not specific to retroviruses? Yes or No?

We are also pleased that Brian Foley agrees with us regarding our definition of an infectious molecular clone; “… by infectious molecular clone of a virus is meant the introduction of the viral genome (molecular clone) into suitable cells leading to the appearance of virus particles identical (regarding both appearance and composition) to the ones from which the genome was obtained”.

Brian Foley stated: “The clone must produce virus particles that are identical by serology, morphology, protein sequences, RFLP, Southern blotting, etc. to the parental virus, and the particles must also be infectious. If a cloned viral genome does not meet these criteria, it is not an INFECTIOUS molecular clone of the virus, be it HIV-1 or any other virus”.

Would Brian Foley please give us a study and a few confirmatory studies where the existence of an “infectious molecular clone” of “HIV” has been proven.

Competing interests: None declared