Re-phrasing our two questions to Brian Foley 11 May 2004
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Eleni Papadopulos-Eleopulos,
Biophysicist
Department of Medical Physics, Royal Perth Hospital, Western Australia, 6001,
Valendar F Turner, John Papadimitriou, Barry Page, David Causer, Helman Alfonso, Sam Mhlongo, Todd Miller, Christian Fiala

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Re: Re-phrasing our two questions to Brian Foley

Re-phrasing our two questions to Brian Foley

In his “Re: Re: Re: Re: Re: Two questions to Brian Foley ”and “Some history on work done by the Gallo and Montagnier groups, 1982-1985”, 6th May Brian Foley responded to our rapid response “Re: Re: Re: Re: Two questions to Brian Foley”, 6 May 2004. Unfortunately he gave a lengthy response and a long list of inappropriate references but did not answer our questions. So let us re-phrase them once again.

Would please Brian Foley read Gallo and Montagnier group’s 1984-1985 papers (1,2,3) and tell us if it is true that the “HIV” poly(A)-RNA, , that is, the “HIV” genome, originated from the 1.16g/ml band? Yes or No?

Is it true that by infectious molecular clone of a virus is meant the introduction of the viral genome (molecular clone) into suitable cells leading to the appearance of virus particles identical (regarding both appearance and composition) to the ones from which the genome was obtained? Yes or No?

References

1. Alizon M, Sonigo P, Barre-Sinoussi P, Chermann JC, Tiollais P, Montagnier L, Wain-Hobson S. (1984). Molecular cloning of lymphadenopathy- associated virus. Nature 312:757-760.

2. Ayra SK, Gallo RC, Hahn BH, Shaw GM, Popovic M, Salahuddin SZ, Wong-Staal F. (1984). Homology of genome of AIDS-associated virus with genomes of human T-cell leukemia viruses. Science 225:927-929

3. Shaw GM, Hahn BH, Arya SK, Groopman JE, Gallo RC, Wong-Staal F. (1984). Molecular characterization of human T-cell leukemia (lymphotropic) virus type III in the acquired immune deficiency syndrome. Science 226:1165-1171.

Competing interests: None declared