Re: gp41 24 October 2003
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Christopher J Noble,
postdoctoral fellow
Bern Switzerland

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Re: Re: gp41

Eleni Papadopulos-Eleopulos claims: "Montagnier considers p41 to be the ubiquitous cellular protein actin."

I have observed that Eleni often appeals to "Orthodox" authorities as supporters of her ideas. Here she tries to convince readers that Montagnier thinks that HIV-gp41 that is present in WBs and ELISAs is just cellular actin. Montagnier most certainly does not say this. To claim that he does is blatantly dishonest. A quick search of the literature demonstrates this. Montagnier coauthored a paper in 1990 which was concerned with the production of monoclonal antibodies to HIV gp41. (1)

Here it is 2003 and Eleni is still saying that Montagnier thinks HIV gp41 is actin.

Since 1983 the genome of HIV has been sequenced. Recombinant proteins such as gp41 have been mass produced and purified. The crystal structures have been determined by X-ray crystallography. There is a wealth of knowledge about this protein and yet Eleni still tries to claim that it is just actin.

HIV gp41 and actin have similar molecular weights. To claim that one cannot tell the difference between the two is like claiming that apples and oranges are identical because they both weigh approximately the same.

The fact that these recombinant proteins react with sera from AIDS patients is not just an accidental coincidence as Eleni would have you believe. It is evidence that demands explanation. Eleni has no explanation for this experimental evidence. Her theory cannot predict this. She would like you to believe that this reaction is just non-specific. This is not true HIV-1 group O gp41 recombinant antigens are specific to sera from patients who also have detectable HIV-1 group O RNA in their blood.

Eleni would like everyone to ignore all of the evidence that has accumulated since 1983. Rather she focusses on the early works of Gallo and Montagnier. This is like trying to disprove heavy than air flight by focussing solely on the early experiments of the Wright brothers and refusing to visit your local international airport in case you might see a jumbo jet landing.

If Eleni wants to she can purchase highly purified HIV gp41 which is used in modern antibody tests such as those I have previously listed.

She can continue to claim that HIV gp41 is actin if she wants but noone will listen to her.

(1) Prigent S, Goossens D, Clerget-Raslain B, Bahraoui E, Roussel M, Tsikas G, Laurent A, Montagnier L, Salmon C, Gluckman JC, et alProduction and characterization of human monoclonal antibodies against core protein p25 and transmembrane glycoprotein gp41 of HIV-1. AIDS 4, 1990 11-9.

Competing interests: None declared