HIV gp41 is not actin 15 October 2003
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Christopher J Noble,
postdoctoral fellow
Bern Switzerland

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Re: HIV gp41 is not actin

Contrary to Eleni Papadopulos-Eleopulos' assertion the Vironostika HIV Uni-Form II plus O contains synthetic peptides based on the immunodominant region of HIV-1 group O gp41. (1)

Eleni Papadopulos-Eleopulos also claims "Montagnier considers p41 to be the ubiquitous cellular protein actin."

This is an often repeated myth that has been propagated by Eleni Papadopulos-Eleopulos.

HIV gp41 has absolutely no relation to actin. Nobody including Montagnier has ever suggested that it has. In the Tahi interview that you cite he clearly distinguishes HIV gp41 from actin. It is true that early viral lysates were contaminated with cellular actin but as you can see newer tests mostly use either recombinant antigens or synthetic peptides.

The only reference you give is from 1983! There is absolutely no confusion between HIV gp41 and cellular actin. Why do you continue to propagate this myth?

(1) van Binsbergen J, de Rijk D, Peels H, Dries C, Scherders J, Koolen M, Zekeng L, Gurtler LG, J. Virol. Methods 60, 1996, 131-7.

Competing interests: None declared