Re: A plea to Eleni Papadopulos-Eleopulos 15 August 2003
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Christopher J Noble,
postdoctoral fellow
Bern Switzerland

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Re: Re: A plea to Eleni Papadopulos-Eleopulos

Eleni Papadopulos-Eleopulos has specifically referred to the genome of the type 3 Sabin poliovirus vaccine several times and has also talked about "all three poliovirus types".

She is then fully aware that there are three different types of poliovirus in the common trivalent oral poliovirus vaccine.

She has also made the specific claim that the genome of the poliovirus does not vary by more than 1%.

The complete genome of all three poliovirus types have been sequenced and are freely available for download at the Entrez Nucleotide database.

It is simple to download the sequences of isolates for each poliovirus type. y.fcgi?cmd=Retrieve&db=nucleotide&li st_uids=27085396&dopt=GenBank ry.fcgi?cmd=Retrieve&db=nucleotide&list _uids=27085398&dopt=GenBank ry.fcgi?cmd=Retrieve&db=nucleotide&li st_uids=27085400&dopt=GenBank

It is also simple to use tools freely available on the internet to align the sequences. For example

The difference between each of the three poliovirus types is about 20%.

If we apply Eleni Papadopulos-Eleopulos' arguments to poliovirus then it also does not exist.

We can all celebrate. Another disease causing virus has been eliminated.

Competing interests:   None declared