Matthias Egger's Study Found up to 65% Reduction in Mortality With Antretroviral Drugs 11 July 2003
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Tony Floyd,
Medical Student
Newcastle University, Newcastle Australia

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Re: Matthias Egger's Study Found up to 65% Reduction in Mortality With Antretroviral Drugs

A prospective multicenter study from Switzerland(1) has drawn some interest from two respondents above.

The results of the study could perhaps best be represented by comparing the reduction in AIDS diagnosis and the reduction in death achieved compared to no treatment:

  Reduction in AIDS Diagnosis Reduction in Mortality
Monotherapy 16% 23%
Dual Therapy 24% 31%
Triple Therapy 42% 65%

The author's conclusion was that the:

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"introduction of antiretroviral combination therapies outside the selected patient groups included in clinical trials has led to comparable reductions in disease progression and mortality."
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The reductions in disease progression and mortality within clinical trials is also a spectacular affirmation of the efficacy of antiretroviral therapy.

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References:

(1) Egger, M. et al. Impact of new antiretroviral combination therapies in HIV infected patients in Switzerland: Prospective multicentre study. British Medical Journal, 315: 1194-9, Nov. 8, 1997

Competing interests:   None declared